Functional chromatographic technique for natural product isolation

Functional chromatographic technique for natural product isolation.

Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

Natural product isolation.

Since the 1990s, interest in natural product research has increased considerably. Following several outstanding developments in the areas of separation methods, spectroscopic techniques, and sensitive bioassays, natural product research has gained new attention for providing novel chemical entities. This updated review deals with sample preparation and purification, recent extraction techniques...

How to Approach the Isolation of a Natural Product

Natural Product Research: Formerly Natural Product Letters

New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities Lei Zhang, Hai-Qing Lin, Gui-Sheng Li, Xi-Dian Yue & ShengJun Dai a School of Pharmaceutical Science, Yantai University, Yantai 264005, P.R. China b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Coll...

Natural Product Research: Formerly Natural Product Letters

Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro Filomena Conforti a , Federica Menichini a , Carmen Formisano b , Daniela Rigano b , Felice Senatore b , Maurizio Bruno c , Sergio Rosselli c & Sezgin Çelik d a Department of Pharmaceutical Sciences , University of Calabria , via ...